Each year, advances in biomedical science save the lives of tens of thousands of children worldwide, prevent or limit disease or disability in many more, and improve the quality of life for countless others. Still, pediatricians and others have long argued that infants, children, and adolescents have not shared equally with adults in biomedical progress. In particular, many drugs that are prescribed for children have not been tested with children. This gap puts them at risk for dosing miscalculations and preventable harms related to metabolic and other differences between children and adults.
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Accepted: October 21, 2004
Received: September 8, 2004
© 2005 Ambulatory Pediatric Association. Published by Elsevier Inc. All rights reserved.