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Uptake of Human Papillomavirus Vaccine Among Adolescent Males and Females: Immunization Information System Sentinel Sites, 2009–2012

      Abstract

      Objective

      The Advisory Committee on Immunization Practices (ACIP) has recommended routine human papillomavirus (HPV) vaccination at age 11 or 12 years for girls since 2006 and for boys since 2011. We sought to describe adolescent HPV vaccination coverage, doses administered from 2009 to 2012, and age at first vaccination by sex.

      Methods

      Aggregate data were analyzed from 8 Immunization Information System sentinel sites on HPV vaccinations in children and adolescents aged 11 to 12 years, 13 to 15 years, and 16 to 18 years. Vaccination coverage by age group was reported for 2009 to 2012, and weekly doses administered were determined. Age at first HPV vaccination was calculated for girls in 2007 and 2011 and for boys in 2011.

      Results

      This analysis included data on 2.9 million adolescents aged 11 to 18 years. There were small increases in coverage for girls, with receipt of ≥1 dose of HPV vaccine reaching 27.1% of ages 11 to 12, 47.9% of ages 13 to 15, and 57.1% of ages 16 to 18 by December 31, 2012. Uptake of ≥1 dose in boys reached ∼18% for all age groups. Doses administered showed seasonal variation, with highest uptake before back to school among girls and steady increases in boys after the 2009 ACIP recommendation for permissive use. Doses administered to boys surpassed those administered to girls by September 2012. Among vaccinated girls, more received vaccine at the recommended age of 11 to 12 years in 2011 (74.2%) compared to 2007 (9.9%). In 2011, 27.3% of vaccinated boys received their first dose at age 11 to 12 years.

      Conclusions

      HPV vaccination coverage increased among adolescents between 2009 and 2012. However, increases among girls were small, and coverage for boys and girls remained below target levels.

      Keywords

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      References

        • Centers for Disease Control and Prevention
        FDA licensure of bivalent human papillomavirus vaccine (HPV2, Cervarix) for use in females and updated HPV vaccination recommendations from the Advisory Committee on Immunization Practices (ACIP).
        MMWR Morb Mortal Wkly Rep. 2010; 59: 626-629
        • Centers for Disease Control and Prevention
        FDA licensure of quadrivalent human papillomavirus vaccine (HPV4, Gardasil) for use in males and guidance from the Advisory Committee on Immunization Practices (ACIP).
        MMWR Morb Mortal Wkly Rep. 2010; 59: 630-632
        • Markowitz L.E.
        • Dunne E.F.
        • Saraiya M.
        • et al.
        Quadrivalent human papillomavirus vaccine. Recommendations of the Advisory Committee on Immunization Practices (ACIP).
        MMWR Recomm Rep. 2007; 56: 1-24
      1. Centers for Disease Control and Prevention. National and state vaccination coverage among adolescents aged 13–17 years—United States, 2012.
        MMWR Morb Mortal Wkly Rep. 2013; 62: 685-693
        • Jain N.
        • Singleton J.A.
        • Montgomery M.
        • Skalland B.
        Determining accurate vaccination coverage rates for adolescents: the National Immunization Survey–Teen 2006.
        Public Health Reports. 2009; 124: 642-651
      2. Centers for Disease Control and Prevention. National, state, and local area vaccination coverage among adolescents aged 13 through 17 years—United States, 2011.
        MMWR Morb Mortal Wkly Rep. 2012; 61: 671-677
        • White K.E.
        • Pabst L.J.
        • Cullen K.A.
        Up-to-date haemophilus influenzae type b vaccination coverage during a vaccine shortage.
        Pediatrics. 2011; 127: e707-e712
        • Centers for Disease Control and Prevention
        Seasonal influenza vaccination coverage among children aged 6 months–18 years—eight immunization information system sentinel sites, United States, 2009–10 influenza season.
        MMWR Morb Mortal Wkly Rep. 2010; 59: 1266-1269
        • Boom J.
        • Dragsbaek A.
        • Nelson C.
        The success of an immunization information system in the wake of Hurricane Katrina.
        Pediatrics. 2007; 119: 1213-1217
      3. Centers for Disease Control and Prevention. Progress in immunization information systems—United States, 2009.
        MMWR Morb Mortal Wkly Rep. 2011; 60: 10-12
        • Williams L.
        • Fiore A.
        • White K.E.
        Influenza vaccination coverage among children aged 6–59 months—eight immunization information system sentinel sites, United States, 2007–08 influenza season.
        MMWR Morb Mortal Wkly Rep. 2008; 57: 1043-1046
      4. Centers for Disease Control and Prevention. Q&A about sentinel sites. Available at: http://www.cdc.gov/vaccines/programs/iis/activities/sentinel-sites.htm. Accessed February 9, 2011.

      5. Immunization Information System. HL7 standard code set. CVX—vaccines administered. Available at: http://www2a.cdc.gov/nip/IIS/IISStandards/vaccines.asp?rpt=cvx. Accessed February 10, 2011.

        • Williams W.
        • Lowery E.
        • Lyalin D.
        • et al.
        Development and utilization of best practice operational guidelines for immunization information systems.
        J Public Health Manag Pract. 2011; 17: 449-456
      6. US Census Bureau. Population and housing unit estimates. Available at: http://www.census.gov/popest/. Accessed July 10, 2012.

      7. Pabst LJ, Papadouka V, Cullen KA, Bartlett DL. Methodological considerations: denominators for Immunization Information System–based vaccine coverage assessments. Paper presented at: 43rd National Immunization Conference; April 1, 2009; Dallas, Texas.

        • Reiter P.L.
        • Gilkey M.B.
        • Brewer N.T.
        HPV vaccination among adolescent males: results from the National Immunization Survey–Teen.
        Vaccine. 2013; 31: 2816-2821
        • Dorell C.G.
        • Yankey D.
        • Santibanez T.A.
        • Markowitz L.E.
        Human papillomavirus vaccination series initiation and completion, 2008–2009.
        Pediatrics. 2011; 128: 830-839
        • Reiter P.L.
        • Brewer N.T.
        • Gottlieb S.L.
        • et al.
        Parents’ health beliefs and HPV vaccination of their adolescent daughters.
        Social Sci Med. 2009; 69: 475-480
        • Chao C.
        • Velicer C.
        • Slezak J.M.
        • Jacobsen S.J.
        Correlates for human papillomavirus vaccination of adolescent girls and young women in a managed care organization.
        Am J Epidemiol. 2010; 171: 357-367
        • Pruitt S.L.
        • Schootman M.
        Geographic disparity, area poverty, and human papillomavirus vaccination.
        Am J Prev Med. 2010; 38: 525-533
        • Gust D.A.
        • Darling N.
        • Kennedy A.
        • Schwartz B.
        Parents with doubts about vaccines: which vaccines and reasons why.
        Pediatrics. 2008; 122: 718-725
        • Gerend M.A.
        • Weibley E.
        • Bland H.
        Parental response to human papillomavirus vaccine availability: uptake and intentions.
        J Adolesc Health. 2009; 45: 528-531
        • Dempsey A.F.
        • Abraham L.M.
        • Dalton V.
        • Ruffin M.
        Understanding the reasons why mothers do or do not have their adolescent daughters vaccinated against human papillomavirus.
        Ann Epidemiol. 2009; 19: 531-538
        • Dempsey A.F.
        • Zimet G.D.
        • Davis R.L.
        • Koutsky L.
        Factors that are associated with parental acceptance of human papillomavirus vaccines: a randomized intervention study of written information about HPV.
        Pediatrics. 2006; 117: 1486-1493
        • Kahn J.A.
        • Rosenthal S.L.
        • Tissot A.M.
        • et al.
        Factors influencing pediatricians’ intention to recommend human papillomavirus vaccines.
        Ambul Pediatr. 2007; 7: 367-373
        • Daley M.F.
        • Crane L.A.
        • Markowitz L.E.
        • et al.
        Human papillomavirus vaccination practices: a survey of US physicians 18 months after licensure.
        Pediatrics. 2010; 126: 425-433
        • Liddon N.
        • Hood J.
        • Wynn B.A.
        • Markowitz L.E.
        Acceptability of human papillomavirus vaccine for males: a review of the literature.
        J Adolesc Health. 2010; 46: 113-123
      8. Knighton C, Thomas E, Stanwyck C. School-entry vaccination laws in the United States, 2009–2010: a brief overview. Paper presented at: 44th National Immunization Conference; April 19–22, 2010; Atlanta, Ga.

      9. Immunization Action Coalition. State mandates on immunization and vaccine-preventable diseases. Available at: http://www.immunize.org/laws/. Accessed October 11, 2012.

      10. School vaccination requirements, exemptions, and Web links. Available at: http://www2a.cdc.gov/nip/schoolsurv/schImmRqmt.asp. Accessed January 24, 2014.

        • Grady D.
        Remark on HPV vaccine could ripple for years.
        New York Times, New York CitySeptember 20, 2011
        • Centers for Disease Control and Prevention
        Human papillomavirus vaccination coverage among adolescent girls, 2007–2012, and postlicensure vaccine safety monitoring, 2006–2013—United States.
        MMWR Morb Mortal Wkly Rep. 2013; 62: 591-595
        • Tsai Y.
        • Zhou F.
        • Wortley P.
        • et al.
        Trends and characteristics of preventive care visits among commercially insured adolescents, 2003–2010.
        J Pediatr. 2014; 164: 625-630
        • Rand C.M.
        • Shone L.P.
        • Albertin C.
        • et al.
        National health care visit patterns of adolescents: implications for delivery of new adolescent vaccines.
        Arch Pediatr Adolesc Med. 2007; 161: 252-259
        • Elster A.
        • Kuznets N.
        AMA Guidelines for Adolescent Preventive Services (GAPS): Recommendations and Rationale.
        Williams & Wilkins, Baltimore, Md1994
        • Dempsey A.
        • Cohn L.
        • Dalton V.
        • Ruffin M.
        Patient and clinic factors associated with adolescent human papillomavirus vaccine utilization within a university-based health system.
        Vaccine. 2010; 28: 989-995
        • Blumberg S.J.
        • Luke J.V.
        • Davidson G.
        • et al.
        Wireless substitution: state-level estimates from the National Health Interview Survey, January–December 2007.
        Natl Health Stat Rep. 2009; 1–13: 16
      11. Copeland KR, Dorell C, Khare M, et al. Assessment of Bias in the National Immunization Survey–Teen: An Updated Benchmark to the National Health Interview Survey. Chicago, Ill: American Association for Public Opinion Research 65th Annual Conference; May 16, 2010.

      12. Montgomery M, Jain N, Singleton JA, Khare M. Assessment of Bias in the National Immunization Survey–Teen: Benchmarking to the National Health Interview Survey. New Orleans, La: American Association for Public Opinion Research 63rd Annual Conference; May 16, 2008.