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Neurotoxicity Outside the Operating Room: An Evolving Challenge for Pediatricians and Pediatric Subspecialists

  • Pradip P. Kamat
    Correspondence
    Address correspondence to Pradip P. Kamat, MD, MBA, FCCM, Division of Pediatric Critical Care Medicine, Children's Healthcare of Atlanta, 1405 Clifton Rd, NE, Atlanta, GA 30322
    Affiliations
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Emory University School of Medicine, Children's Healthcare of Atlanta (PP Kamat), Atlanta, Ga
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  • Harold K. Simon
    Affiliations
    Division of Pediatric Emergency Medicine, Departments of Pediatrics and Emergency Medicine, Emory University School of Medicine, Children's Healthcare of Atlanta (HK Simon and C Sulton), Atlanta, Ga
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  • Carmen Sulton
    Affiliations
    Division of Pediatric Emergency Medicine, Departments of Pediatrics and Emergency Medicine, Emory University School of Medicine, Children's Healthcare of Atlanta (HK Simon and C Sulton), Atlanta, Ga
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  • Sapna R. Kudchadkar
    Affiliations
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Charlotte R. Bloomberg Children's Center (SR Kudchadkar), Baltimore, Md

    Department of Pediatrics, Johns Hopkins University School of Medicine, Charlotte R. Bloomberg Children's Center (SR Kudchadkar), Baltimore, Md

    Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Charlotte R. Bloomberg Children's Center (SR Kudchadkar), Baltimore, Md
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  • Jessica Raper
    Affiliations
    Yerkes National Primate Research Center, Emory University, Atlanta, GA USA, Department of Pediatrics, Emory University School of Medicine, Atlanta, Ga
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Published:October 09, 2021DOI:https://doi.org/10.1016/j.acap.2021.10.001
      Preclinical and clinical studies of anesthesia/sedation related potential neurotoxicity in children under three years of age report that a single general anesthesia exposure was associated with statistically significant increases in parent reports of behavioral problems with no difference in general intelligence.

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